AUTHOR: SEOK WOO YANG, MD & PhD (soplab@outlook.kr)
DATE: 2020.03.05
CONTENT:
About ethanol as a sterilizing agent
Kariwa et al(2020) reported below facts:
70% ethanol reduced viral infectivity below the detectable level.
There can be a question about how ethanol inactivates viral particles.
About this, Toppozine et al(2012) reported the evidence for enhanced permeability in both fluid and gel phases of the phospholipid bilayers in the presence of ethanol molecules.
Coronaviruses' outline is composed of envelope structure, which is composed of lipid bilayer. The permeability of this lipid can be increased by ethanol.
For this reason, ethanol as a disinfectant for Coronaviruses can be useful.
REFERENCE:
1. Kariwa H, Fujii N, Takashima I. Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents. Dermatology. 2006;212 Suppl 1:119-23. doi: 10.1159/000089211. PMID: 16490989.Date: 2020.03.05
2. Laura Toppozini, Clare Armstrong, Matthew A. Barrett, Songbo Zheng, Lindy Luo, Hirsh Nanda, Victoria Garcia Sakai, Maikel C. Rheinstadter. Partitioning of ethanol into lipid membrane and its effect on fluidity and permeability as seen by X-ray and neurtron scattering. Soft Matter, issue 47, 2012.
DATE: 2020.03.05
The PDF download site of reference 1: https://www.karger.com/Article/Pdf/89211
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